Clinical Trials & Research

In this study, researchers examine the effects of a drug, fluoxetine, in improving the functional ability of those facing stroke recovery.   Stroke affects many worldwide. Disability is one of the debilitating effects after a stroke.  It is estimated that 6.5 million people worldwide are affected by post-stroke disability. Usually, post-stroke recovery involves treating depression
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Researchers at Virginia Tech are testing a new drug for chronic pain treatment that may avoid the addictive effects of opioids. Non-steroidal anti-inflammatory drugs (NSAIDs) such as aspirin are commonly used for mild and moderate generalized pain but may have limited effectiveness in alleviating chronic nerve pain. NSAIDs inhibit the activity of cyclooxygenase enzymes responsible
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Our Reader Score [Total: 0 Average: 0] Despite the rising number of peanut-allergic children in North America, no FDA approved food allergy treatment is available. A recent phase-3 trial tested a new oral peanut allergy treatment in children and adolescents. There is currently no treatment for allergy symptoms caused by peanut proteins. Peanut-allergic patients are
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Our Reader Score [Total: 0 Average: 0] An exciting study published in Science Translational Medicine has identified a novel protein which could aid in early diagnosis and lung cancer treatment. It has been established that many tumors rely on a constant glucose supply for supporting their growth. As the cancer cells continue to grow, many
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Our Reader Score [Total: 2 Average: 5] A clinical trial of a new anti-cholesterol drug has generated promising results in reducing the chances of a second heart attack, unstable angina, or death from coronary heart disease. Acute coronary syndrome is a life-threatening health condition associated with sudden and reduced blood flow to the heart. The
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Our Reader Score [Total: 0 Average: 0] A recent study published in Cancer Discovery has highlighted yet another example of how a combination of chemotherapy and immunotherapy could be a way to treat acute myeloid leukemia. Acute myeloid leukemia is a type of cancer that originates in bone marrow, the site for the formation of blood cells
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Our Reader Score [Total: 0 Average: 0] A dendritic cell-based vaccine targeting HER2 has shown immense promise in a phase-1 clinical trial, as presented at the CRI-CIMT-EATI-AACR International Cancer Immunotherapy Conference. HER2 is a type of receptor that is found on the surface of certain cancer cells. Specific hormones and growth factors can bind to
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Our Reader Score [Total: 0 Average: 0] A dendritic cell-based vaccine targeting HER2 has shown immense promise in a phase-1 clinical trial, as presented at the CRI-CIMT-EATI-AACR International Cancer Immunotherapy Conference. HER2 is a type of receptor that is found on the surface of certain cancer cells. Specific hormones and growth factors can bind to
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Our Reader Score [Total: 0 Average: 0] A dendritic cell-based vaccine targeting HER2 has shown immense promise in a phase-1 clinical trial, as presented at the CRI-CIMT-EATI-AACR International Cancer Immunotherapy Conference. HER2 is a type of receptor that is found on the surface of certain cancer cells. Specific hormones and growth factors can bind to
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Our Reader Score [Total: 5 Average: 5] A first-in-human clinical trial of a new drug has generated promising results in reducing vascular calcification of hemodialysis patients. Vascular calcification is the leading cause of death in patients with end-stage renal disease undergoing hemodialysis. According to The US Renal Data System, nearly 50% of patients with end-stage
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Our Reader Score [Total: 7 Average: 5] A first-in-human clinical trial of a new drug has generated promising results in reducing vascular calcification of hemodialysis patients. Vascular calcification is the leading cause of death in patients with end-stage renal disease undergoing hemodialysis. According to The US Renal Data System, nearly 50% of patients with end-stage
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Our Reader Score [Total: 7 Average: 5] A first-in-human clinical trial of a new drug has generated promising results in reducing vascular calcification of hemodialysis patients. Vascular calcification is the leading cause of death in patients with end-stage renal disease undergoing hemodialysis. According to The US Renal Data System, nearly 50% of patients with end-stage
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Our Reader Score [Total: 7 Average: 5] A first-in-human clinical trial of a new drug has generated promising results in reducing vascular calcification of hemodialysis patients. Vascular calcification is the leading cause of death in patients with end-stage renal disease undergoing hemodialysis. According to The US Renal Data System, nearly 50% of patients with end-stage
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Our Reader Score [Total: 5 Average: 5] A first-in-human clinical trial of a new drug has generated promising results in reducing vascular calcification of hemodialysis patients. Vascular calcification is the leading cause of death in patients with end-stage renal disease undergoing hemodialysis. According to The US Renal Data System, nearly 50% of patients with end-stage
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Our Reader Score [Total: 0 Average: 0] Due to a complex and poorly understood mechanism of action, only two medications are currently approved for the treatment of ALS.  A multicentre trial was recently carried out in Germany to determine whether rasagiline could improve survival rates in patients with ALS when used with one of these
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Our Reader Score [Total: 0 Average: 0] A clinical trial that used sildenafil (Viagra) to treat pregnant women with fetal growth restriction was stopped early due to deaths. Severe early-onset fetal growth restriction is a complication that occurs in about 0.4% of pregnant woman and usually results in the birth of a premature baby, a
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Our Reader Score [Total: 1 Average: 5] A recent study in the NEJM describes the outcome of a large clinical trial that compared cardiovascular risks of febuxostat or allopurinol for gout treatment. Gout is a kind of arthritis that occurs due to the formation of urate crystals within the bone joints. Uric acid, a substance
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Our Reader Score [Total: 9 Average: 3.7] A group of researchers in the US modified the existing chemotherapy with humanized antibodies to improve lung cancer survival rates. Lung cancer is the leading cause of death from cancer in Canada. According to The Canadian Cancer Society, about 28,600 Canadians were diagnosed with lung cancer in 2017.
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Our Reader Score [Total: 0 Average: 0] A clinical trial of stroke treatments showed that giving three antiplatelet therapy drugs had no benefit over two, and was associated with more bleeding. Recent large-scale clinical trials have shown that starting treatment with two antiplatelet therapy drugs after a stroke, rather than just one, reduces the risk
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Our Reader Score [Total: 1 Average: 5] Stem cell clinical trials have the potential to treat and cure genetic and degenerative diseases. However, many recent trials have sacrificed scientific quality and health safety to push quicker clinical trials. Concerned researchers advocating for better clinical trial have proposed new guidelines to deter substandard clinical trials. Stem
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Our Reader Score [Total: 1 Average: 2] A recent trial testing the effectiveness of rivaroxaban against aspirin in recurrent stroke prevention was terminated due to risk-benefit concerns. Ischemic strokes occur when blood vessels in the brain become obstructed by blood clots. Approximately 1 in 5 strokes are of the embolic subtype, meaning that the blood
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Our Reader Score [Total: 1 Average: 4] Most treatments for multiple sclerosis concentrate on managing symptoms and slowing disease progression. A recent phase-3 trial investigated whether natalizumab is effective in treating secondary progressive multiple sclerosis. Canada has one of the highest incidences of multiple sclerosis (MS) worldwide. An autoimmune disease, MS targets the protective covering
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Our Reader Score [Total: 0 Average: 0] The results of a phase-3 trial were recently published comparing the effectiveness of postoperative chemotherapy with chemoradiotherapy for gastric cancer. Gastric carcinoma is a form of cancer that originates in the lining of the stomach. This form of cancer is rare in comparison to other types of cancer.
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Our Reader Score [Total: 0 Average: 0] Investigator brochures are key documents in the regulatory approval process before initiating clinical trials. A recent study by German and Canadian researchers investigated just how effective these documents are at enabling accurate risk-benefit assessments. The main purpose of early-phase clinical research is to establish the safety and dosing
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Our Reader Score [Total: 0 Average: 0] Despite being the gold standard, a recent publication in Annals of Medicine suggests that randomized controlled trials may not be as unbiased as scientists believe. Randomization is an important element of modern clinical trials. It refers to the process of randomly allocating participants to either the experimental or
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